NCR3LG1 - natural killer cell cytotoxicity receptor 3 ligand 1 Gene

Also Known as B7H6; B7-H6; DKFZp686O24166

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 374383

About NCR3LG1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,351,800-17,381,661 (from NCBI)

This gene has 2 transcripts (splice variants), 83 orthologues and 2 paralogues. Broad expression in colon (RPKM 2.1), duodenum (RPKM 1.9) and 21 other tissues.

Summary

B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

NCR3LG1 Products (1)

mRNA Protein Name
NM_001202439.3 NP_001189368.1 natural cytotoxicity triggering receptor 3 ligand 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19528259 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
19528259 GOA
Biological Process GO Annotation Evidence References Source
involved in NK T cell activation IDA
IDA: Inferred from direct assay
19528259 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
19528259 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCR3LG1 Protein Structure

C1-set

C1-set: Immunoglobulin C1-set domain (160 - 239)

Gag_MA

Gag_MA: Matrix protein (MA), p15 (295 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

natural cytotoxicity triggering receptor 3 ligand 1

  • B7 homolog 6

NCR3LG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NCR3LG1 Q68D85 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra
NCR3LG1 Q68D85 NRAC Homo sapiens Q8N912
Validated Y2H
32296183
Intra
NCR3LG1 Q68D85 NCR3 Homo sapiens O14931
Confocal
24275655
Intra
NCR3LG1 Q68D85 NCR3 Homo sapiens O14931
ELISA
24275655
Intra
NCR3LG1 Q68D85 NCR3 Homo sapiens O14931
FACS
24275655
Intra
NCR3LG1 Q68D85 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra
NCR3LG1 Q68D85 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra
NCR3LG1 Q68D85 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
NCR3LG1 Q68D85 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCR3LG1 Proteins

Cat. No. Product Name Accession Purity
HY-P7631 B7-H6 Protein, Human (HEK293, His) Q68D85 (D25-S262) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72839 B7-H6 Protein, Human (HEK293, Fc) Q68D85 (D25-S262) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78076 B7-H6 Protein, Human (Biotinylated, HEK293, His-Avi) Q68D85 (D25-S262) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78928 B7-H6 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q68D85 (D25-S262) ≥ 95%, as determined by reducing SDS-PAGE.

NCR3LG1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81609 B7H6 Antibody (YA1354) WB, ICC/IF, IP, FC Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09101 NCR3LG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27148 Ncr3lg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29456 Ncr3lg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NCR3LG1 VGNC VGNC:81975
Rattus norvegicus NCR3LG1 RGD RGD:1588614
Canis familiaris NCR3LG1 VGNC VGNC:52271
Others NCR3LG1 NCBI